The short answer
Look at the controller first. Most CO2 lasers from 50 W upwards — including many OMTech, Monport, Thunder Laser and Boss Laser machines — use a Ruida controller. For those, RDWorks is the free vendor software but runs only on Windows and feels dated; LightBurn is the paid standard on Windows, macOS and Linux; Vextrify drives Ruida-based CO2 lasers from macOS and Windows and prepares photos and designs in the same app. A stock K40 with an M2 Nano board is a separate case — see the K40 guide.
- Most 50 W+ CO2 lasers → Ruida controller
- RDWorks → free, Windows only
- Vextrify → Mac + Windows, camera and photo prep