The short answer
Every laser needs three things kept separate: its connection, its settings and calibration, and its job. LightBurn handles this with one window per laser, opened through File > New Window, each pointed at its own port. Vextrify keeps everything in one window with a tab per laser, and each tab owns its connection, profile, camera calibration and job.
- LightBurn: a separate window per laser
- Vextrify: a tab per laser in one window
- Each laser keeps its own camera and settings